LC–UV/MS quality analytics of paediatric artemether formulations

LC–UV/MS quality analytics of paediatric artemether formulations

A highly selective and stability-indicating HPLC-method, combined with appropriate sample preparation steps, is developed for β-artemether assay and profiling of related impurities, including possible degradants, in a complex powder for oral suspension. Following HPLC conditions allowed the required selectivity: a Prevail organic acid (OA) column (250 mm×4.6 mm, 5 μm), flow rate set at 1.5 mL/m...

Microbiological Quality of Paediatric Oral Liquid Drug Formulations during Consumption

This preliminary study was conducted to evaluate the microbiological quality of paediatric oral liquid drug formulations during consumption. Paracetamol, Salbutamol, Cephalexin, Amoxicillin and Lactulose are few oral liquid medicines prescribed in Sri Lanka. These oral liquid medicines are at a greater risk of microbial contamination during consumption. This can lead to co-infection in paediatr...

Preformulation Studies of Artemether, Quinine and Artemether-Lumefantrine Intended for Fixed-Dose Suppository Formulations

Carvedilol stability in paediatric oral liquid formulations

front matter & 2009 a.2010.01.002 author. : diegochiappetta@y Abstract Objective: Two carvedilol aqueous solutions and one carvedilol aqueous suspension for paediatric oral use (1mg/ml) were studied to determine their stability. Method: All samples were stored at 4, 25 and 401C. Carvedilol content of each of the three formulations was tested using high performance liquid chromatography (HPLC). ...

Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis.

Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria. The study sought to determine the existence of substandard and/or counterfeit artemether-lumefantrine tablets and suspension as well as artemether injection on the market in Cape Coast. S...